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Aminoglycoside-induced production of reactive oxygen species may additionally injure cells of the cochlea. Noise at eighty five dB SPL or above added to the quantity of hair cell death within the excessive frequency region of the cochlea in chinchillas. Ototoxicity is the property of being toxic to the ear (oto-), particularly the cochlea or auditory nerve and sometimes the vestibular system, for example, as a aspect effect of a drug. Examples of ototoxicity grades for hearing loss are the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE), Brock's Hearing Loss Grades, Tune grading system, and Chang grading system. The most common negative effects embody upset stomach, flushing, sensivity to gentle, nausea. So down the left-hand side you've bought all the totally different bits of the documentation, and each certainly one of them is a header and a hyperlink. Most published guidelines from world wide focus on the ototoxicity of medications, but there just isn't consensus on one universally agreed-upon protocol.
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